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Table 5 Expression of nAChR in HBE and Bronchial Epithelial Cell Lines as determined by Immunoblot

From: Nicotine signals through muscle-type and neuronal nicotinic acetylcholine receptors in both human bronchial epithelial cells and airway fibroblasts

HBE

α1

α3

α5*

α7

β1

β2

δ

Never smoker

5/8 (63%)

1/4 (25%)

0/4 (0%)

0/4 (0%)

1/4 (25%)

3/5 (60%)

3/4 (75%)

Active

2/2 (100)

n.d.

2+/2 (100%)

0/2 (0%)

2/2 (100%)

2/2 (100%)

n.d.

Ex-smoker

5/7 (71%)

1/5 (20%)

5+/7 (71%)

0/7 (0%)

4/7 (57%)

5/5 (100%)

5/5 (100%)

Total

12/17 (71%)

2/9 (22%)

7/13 (54%)

0/13 (0%)

7/13 (54%)

10/12 (83%)

6/6 (100%)

BEAS2B

+

-

+

-

+

-

+

IB3-1

+

-

+

-

+

+

+

  1. nAChR subunit protein present in HBE and bronchial epithelial cell lines as determined by immunoblot. The table indicates the number of positive cultures out of the total number of cultures examined, as well as the percentage of positive cultures for each subunit. * indicates statistical significance when comparing never smoking samples to combined active and ex-smoker samples. + The α5 subunit was present in these samples, but at low levels compared to other subunits and control.
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Respiratory Research

ISSN: 1465-993X

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