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Table 2 Growth factors determined by real-time PCR. Among growth factors and receptors that were described to be regulated, TSP-1, VEGF-R1 (Flt), PDGF-B, Serum Response Factor (SRF), TGF-β 1, Angiopoietin Receptor 2 (TIE2) and FGF-2 were separately determined by relative mRNA quantification after laser-microdissection from 1 and 7 day hypoxic/normoxic intrapulmonary arteries. Mean ± SEM is given from n = 4 independent experiments.

From: Expression profiling of laser-microdissected intrapulmonary arteries in hypoxia-induced pulmonary hypertension

Genes

1 Day Hypoxia

7 Days Hypoxia

Thrombospondin 1 (TSP-1)

4.61 ± 0.79

1.95 ± 0.44

VEGF-R1/FLT1

2.38 ± 0.43

0.61 ± 0.13

PDGF-β

1.41 ± 0.28

2.96 ± 0.82

Serum Response Factor (SRF)

1.09 ± 0.08

1.70 ± 0.29

Transforming Growth Factor β 1 (TGF-β 1)

0.94 ± 0.14

2.10 ± 0.46

Angiopoietin Receptor 2 (TIE2)

0.91 ± 0.09

1.94 ± 0.21

Fibroblast Growth Factor 2 (FGF-2)

0.75 ± 0.14

0.80 ± 0.15