Uncoordinated production of Laminin-5 chains in airways epithelium of allergic asthmatics

Respiratory Research

Table 2 The thickness of various laminin chains in SEBM (μm)

Laminin chain	Healthy controls	Allergic asthma	Non-allergic asthma
α₁-chain	No staining	Patchy, weak staining	No staining
α₂-chain	1.94 (1.70–2.20)	2.83 (2.50–3.30)**, ‡‡‡	2.19 (1.8–2.90)
α₃-chain	2.46 (1.80–3.10)	3.77 (3.30–4.40)***, ‡‡‡	2.61 (2.20–3.10)
α₄-chain	No staining	No staining	No staining
α₅-chain	2.31 (1.90–2.50)	4.10 (3.30–4.60)***, ‡‡‡	2.86 (2.40–3.50) **
β₁-chain	2.13 (1.60–2.80)	4.84 (4.10–5.50)***, ‡‡‡	3.29 (3.10–3.80) ***
β₂-chain	1.93 (1.60–2.60)	2.34 (2.10–2.800)*, ‡‡	2.04 (1.80–2.300)
γ₁-chain	2.47 (1.90–3.00)	4.86 (4.20–5.40) ***, ‡‡‡	3.49 (2.90–3.90) ***
γ₂-chain	2.03 (1.70–2.40)	2.96 (2.60–3.50)**, ‡‡‡	2.36 (2.00–2.80)

Results are given as medians and interquartile ranges. Differences between groups were calculated by the Mann-Whitney non-parametric test and statistical differences shown in the table. **, *** indicate p < 0.01 and p < 0.001, respectively, in the comparison between either of the two asthma groups with the results of the healthy controls. ‡, ‡‡, ‡‡‡ indicate p < 0.05, <0.01 and 0.001, respectively, in the comparison between the two asthma groups.

ISSN: 1465-993X