Variation in conserved non-coding sequences on chromosome 5q and susceptibility to asthma and atopy

Donfack, Joseph; Schneider, Daniel H; Tan, Zheng; Kurz, Thorsten; Dubchak, Inna; Frazer, Kelly A; Ober, Carole

doi:10.1186/1465-9921-6-145

Respiratory Research

Table 4 Allele and genotype frequencies in case and control samples. The number of individuals in each sample is shown in parentheses. Not all individuals in the samples were genotyped for all SNPs. Only SNP2-T showed a modest association with allergic sensitization to mold allergens in European Americans (P _uncorrected = 0.04).

From: Variation in conserved non-coding sequences on chromosome 5q and susceptibility to asthma and atopy

	European Americans				African Americans
SNP	All Asthma	+SPT Any Allergen	+SPT Molds	Controls	All Asthma	+SPT Any Allergen	+SPT Molds	Controls
	(N = 126)	(N = 82)	(N = 46)	(N = 205)	(N = 205)	(N = 160)	(N = 68)	(N = 183)
IL13_-1112T	0.259	0.264	0.275	0.213	0.418	0.409	0.375	0.407
CC	0.576	0.586	0.550	0.613	0.337	0.336	0.391	0.360
CT	0.330	0.300	0.350	0.348	0.489	0.510	0.469	0.467
TT	0.094	0.114	0.100	0.039	0.174	0.154	0.140	0.173
IL13_+1923T	0.245	0.282	0.238	0.227	0.666	0.664	0.672	0.660
CC	0.575	0.535	0.575	0.584	0.087	0.094	0.094	0.133
CT	0.359	0.366	0.375	0.376	0.495	0.483	0.469	0.413
TT	0.066	0.099	0.050	0.040	0.418	0.423	0.437	0.454
IL13_Gln (T)	0.221	0.254	0.272	0.202	0.192	0.191	0.161	0.169
Arg/Arg (C/C)	0.618	0.577	0.625	0.620	0.643	0.639	0.695	0.686
Arg/Gln (C/T)	0.324	0.338	0.325	0.355	0.330	0.340	0.288	0.290
Gln/Gln (T/T)	0.058	0.085	0.05	0.025	0.027	0.021	0.077	0.024
IL4_-589T	0.193	0.197	0.163	0.163	0.677	0.678	0.687	0.643
CC	0.670	0.662	0.700	0.702	0.115	0.128	0.125	0.133
CT	0.274	0.282	0.275	0.270	0.397	0.389	0.375	0.447
TT	0.056	0.056	0.025	0.028	0.478	0.483	0.5	0.420
CNE-C_SNP2-T	0.196	0.223	0.257	0.146	0.405	0.419	0.404	0.382
CC	0.667	0.600	0.541	0.730	0.333	0.316	0.333	0.382
CT	0.294	0.354	0.405	0.247	0.524	0.530	0.526	0.471
TT	0.049	0.046	0.054	0.023	0.143	0.154	0.141	0.147
SNP4-A	0.176	0.186	0.187	0.175	0.399	0.412	0.415	0.359
GG	0.692	0.661	0.656	0.675	0.340	0.323	0.321	0.415
GA	0.264	0.305	0.313	0.300	0.525	0.531	0.528	0.452
AA	0.044	0.034	0.031	0.025	0.135	0.146	0.151	0.132
IL4_+3017T	0.327	0.339	0.387	0.308	0.850	0.867	0.825	0.805
GG	0.490	0.452	0.382	0.478	0.045	0.061	0.067	0.051
TG	0.367	0.419	0.471	0.429	0.209	0.217	0.217	0.288
TT	0.143	0. 129	0.147	0.093	0.746	0. 727	0.716	0.661
IL4_+8374G	0.161	0.164	0.135	0.159	0.275	0.274	0.259	0.257
AA	0.708	0.687	0.730	0.703	0.526	0.533	0.554	0.541
AG	0.261	0.299	0.270	0.275	0.398	0.387	0.375	0.404
GG	0.031	0.014	0	0.022	0.076	0.080	0.071	0.055
SNP7-G	0.279	0.318	0.319	0.317	0.636	0.638	0.614	0.568
AA	0.548	0.485	0.472	0.458	0.156	0.152	0.123	0.213
AG	0.347	0.394	0.417	0.450	0.416	0.421	0.526	0.460
GG	0.105	0.121	0.111	0.092	0.428	0.427	0.351	0.327
CNE-F_SNP8-C	0.323	0.339	0.386	0.293	0.618	0.623	0.598	0.577
CC	0.131	0.113	0.143	0.081	0.393	0.401	0.328	0.335
CG	0.384	0.452	0.486	0.422	0.450	0.444	0.541	0.484
GG	0.485	0.435	0.371	0.497	0.157	0.156	0.131	0.181

Back to article page

ISSN: 1465-993X

Contact us

General enquiries: journalsubmissions@springernature.com