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Table 7 Proposed algorithm for the classification of chronic rhinosinusitis. The numbers of subjects in each category and for each variable were extrapolated to a sample size of 100 based on the current data. The 4 categories were generated from the 3rd Decision. The numbers of projected subjects per category (and % per category) were shown in each column. The far right column gives the sum for each variable per 100 CRS subjects.

From: Pathophysiological classification of chronic rhinosinusitis

Chronic Rhinosinusitis (CRS; n = 100)

1st Decision: Polyps

CRS with Nasal Polyps

CRS without Nasal Polyps

N

 

Present: N = 50.5

Absent: N = 49.4

50.5

2nd Decision: Aspirin sensitivity

Nasal Polyps with Aspirin Sensitivity (NPasa)

Nasal Polyps with Other Features (NPother)

CRS without (s) Nasal Polyps (CRSsNP)

Osteomeatal Complex Disease (OMC)

 
 

17.1 (airways)

0

3.6 (urticaria)

4.8 (urticaria)

25.5

3rd Decision: Sinus mucosal thickening

17.1

33.3

28.3

21.2 (normal sinuses)

78.7

4th Decision:

FEV1/FVC<70%

FEF25%–75%<70%

12.8 (75%)

15.6 (91%)

13.7 (41%)

18.3 (55%)

5.9 (21%)

8.2 (29%)

3.0 (14%)

9.1 (43%)

35.4

51.2

5th Decision:

Peripheral eosinophils >4% Eos. + asthma:

a. atopic

b. nonatopic

c. Eos/no asthma

11.1 (65%)

3.0 (18%)

8.0 (47%)

0.0 (0%)

13.1 (39%)

6.9 (21%)

3.0 (9%)

3.0 (9%)

9.4 (33%)

5.9 (21%)

2.0 (7%)

1.0 (4%)

4.0 (19%)

0 (0%)

2.0 (9%)

2.0 (9%)

37.6

15.8

15.0

6.0

6th Decision:

IgE < 10 IU/ml

Low IgE + low IgG1 or IgG3

4.9 (29%)

2.4 (14%)

5.5 (17%)

1.4 (4%)

12.5 (44%)

9.0 (32%)

9.5 (45%)

2.1 (10%)

32.4

14.9

7th Decision:

Positive allergy skin tests

a. seasonal only

b. persistent

c. negative

d. Excess atopy cases per group

7.5 (44%)

1.0 (6%)

6.5 (38%)

9.6 (56%)

-0.3 (-2%)

23.6 (71%)

1.0 (3%)

22.6 (68%)

9.7 (29%)

7.9 (24%)

19.2 (68%)

2.0 (7%)

17.3 (61%)

9.1 (32%)

7.1 (25%)

8.7 (41%)

0 (0%)

8.7 (41%)

12.5 (59%)

-2.0 (-9%)

59.0

4.0

55.1

40.9

12.7

Total per Group

17.1 (100%)

33.3 (100%)

28.3 (100%)

21.2 (100%)

99.9