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Table 3 Epitope mapping of VN04-2

From: Passive immunoprophylaxis and therapy with humanized monoclonal antibody specific for influenza A H5 hemagglutinin in mice

Virus

HI Titer

Amino acid position in HA1

    

140s Loop

150s Loop

  

94

124

138

140

141

154

155

156

A/Vietnam/1203/04

+++

D

S

Q

K

S

N

S

T

A/Hong Kong/213/03

+++

.

.

.

.

.

.

N

A

A/Dk/Hong Kong/2986.1/00*

+++

.

N

.

.

.

.

.

A

A/Mdk/Jiang Xi/1653/05*

++

.

N

L

.

P

.

.

A

A/Mdk/Jiang Xi/2136/05*

-

N

D

.

R

.

.

N

A

A/Dk/Vietnam/568/05*

-

N

D

.

N

.

.

D

A

A/Qing Hai/05*

-

N

D

.

R

.

.

N

A

  1. Viruses where HI assay titer data was taken from Chen et al, 2006 [26] are highlighted by asterix. Residues matching that in A/Vietnam/1203/04 are represented by full stop. Residue numbering refers to the position in A/Vietnam/1203/04.
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Respiratory Research

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