Table 1 Effects of VEGF administration or inhibition in animal models.
From: Clinical implications for Vascular Endothelial Growth Factor in the lung: friend or foe?
Intervention | Result | Reference |
|---|---|---|
Provocation of intratracheal VEGF overexpression in mice | Dose-dependent increase in extravascular lung water intra-alveolar edema, and increased pulmonary capillary permeability. | [19] |
Administration of a VEGFR inhibitor in mice | Decrease in bronchial hyperresponsiveness and migration of inflammatory cells through the endothelial basement membrane and reduction of VEGF-induced plasma leakage. | [42] |
Intraperitoneal administration of a VEGF receptor blocker in rats | Induction of alveolar septal cell apoptosis and enlargement of air spaces (emphysema). | [46] |
VEGF gene transfer in immature rabbits | Reduction of bleomycin-induced pulmonary hypertension. | [78] |
Blockade of VEGF activity in malignant pleural effusion model in mice | Decrease of vascular permeability and reduction of pleural fluid. | [3, 113] |