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Table 4 Inflammatory cytokine concentrations in airways from CF and wild-type (WT) mice at the indicated time points after a single dose of P aeruginosa LPS with and without pre-treatment with azithromycin (10 mg/kg/day), by oral administration, for 4 weeks.

From: Azithromycin reduces spontaneous and induced inflammation in ΔF508 cystic fibrosis mice

   

MIP-2 pg/ml

TNF-α pg/ml

IL-10 pg/ml

CF

LPS 3 h

AZM-

3966.7 ± 230.3

4041.1 ± 347.6

ND

  

AZM+

3800.8 ± 106.2

2648.1 ± 386.3*

ND

 

LPS 24 h

AZM-

489.1 ± 20.4

282.3 ± 42.6

ND

  

AZM+

300.4 ± 35.9†

251.9 ± 43.3

ND

 

LPS 48 h

AZM-

166.9 ± 19.6

40.5 ± 9.7

25.2 ± 3.2

  

AZM+

220.1 ± 26.9

14.2 ± 3.1*

30.2. ± 4.4

WT

LPS 3 h

AZM-

3933.3 ± 264.6

3805.2 ± 355.6

ND

  

AZM+

4254.2 ± 142.0

4368.5 ± 362.5

ND

 

LPS 24 h

AZM-

169.8 ± 35.3

368.9 ± 84.6

ND

  

AZM+

230.0 ± 31.9

361.6 ± 29.9

ND

 

LPS 48 h

AZM-

328.1 ± 13.5

114.9 ± 8.0

40.5 ± 6.4

  

AZM+

340.0 ± 10.1

111.0 ± 11.1

36.7 ± 2.2

  1. Values are means ± SEM for 6–9 animals per each of the 12 subgroups from the same experiment as that used to generate Table 3. *p < 0.05; †p < 0.005 and ‡p < 0.0005 for comparison of corresponding mean value vs. that obtained for the same parameter at the same time point without pre-treatment with azithromycin. ND = below corresponding detectable levels.