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Table 1 Effect of As2O3 on EOS recruitment in BALF (%), pulmonary NF-κB activity (relative intensity units) and IκBα expression (IκBα/β-actin).

From: Arsenic trioxide, a potent inhibitor of NF-κB, abrogates allergen-induced airway hyperresponsiveness and inflammation

Asthma

 

Control

As2O3

 
 

4 hrs

1 hr

4 hrs

12 hrs

24 hrs

4 hrs

EOS

0.56 ± 0.22

5.08 ± 1.37*

11.12 ± 1.93*

20.25 ± 2.99*

48.72 ± 5.38*

4.69 ± 1.21*†

NF-κB

51.47 ± 4.53

162.31 ± 9.46*

255.74 ± 11.10*

127.59 ± 8.72*

80.97 ± 6.15#

75.80 ± 9.33*†

IκBα

0.80 ± 0.25

0.45 ± 0.04*

0.23 ± 0.10*

0.36 ± 0.03*

0.54 ± 0.07#

1.56 ± 0.34*†

  1. Data represent the mean ± SEM of four independent experiments (n = 6 per group). # p < 0.05, * p < 0.01, vs the control mice; † p < 0.01, vs the OVA-challenged mice at 4 hrs.
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Respiratory Research

ISSN: 1465-993X

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