Figure 7
Oxidative stress can increase the expression inflammatory genes such as interleukin (IL)-8, matrix metalloproteinase (MMP) and monocyte chemotactic protein (MCP) by up-regulating NF-κB activity (a). Oxidative stress can also prevent glucocorticoid receptor (GR) function by (b) suppression of GR-associated histone deacetylase 2 (HDAC2) activity and expression since HDAC2 is recruited by GR to NF-κB to switch off inflammatory gene expression.