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Figure 3 | Respiratory Research

Figure 3

From: Alterations in vasodilator-stimulated phosphoprotein (VASP) phosphorylation: associations with asthmatic phenotype, airway inflammation and β2-agonist use

Figure 3

VASP phosphorylation in epithelial cells of asthmatics after regular albuterol or placebo inhalation. Ratio of 50/46 KD VASP in asthmatic epithelial cells without BAL cell co-culture from subjects either on regular albuterol inhalation (A) or on regular placebo inhalation (B). Epithelial cells were obtained from unchallenged lung segments (Days 1, and 18, broken lines), from Ag challenged lung segments (Days 2, and 19, solid lines) and from resampled lung segments on Day 25 (unchallenged Day 1 segment, and challenged Day 2 segment). Two weeks of regular β2-agonist inhalation, but not placebo inhalation, resulted in significantly increased phosphorylation of VASP in both unchallenged and challenged lung segments' epithelium (p = 0.009). Overall, VASP phosphorylation, i.e. a larger 50/46 KD VASP ratio, was greater in epithelium from challenged than from unchallenged lung segments in the regular β2-agonist inhalation protocol (p = 0.017), but not in the placebo inhalation protocol (B panel).

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