Skip to main content
Figure 2 | Respiratory Research

Figure 2

From: Lung development in laminin γ2 deficiency: abnormal tracheal hemidesmosomes with normal branching morphogenesis and epithelial differentiation

Figure 2

Deposition of laminin chains. Sections from newborn littermate control (b, d, f, h, j, l, n, p) and Lamc2-/- lungs (a, c, e, g, i, k, m, o) were stained with antibodies to laminins α1–5 and γ1–2. The laminin α1 (a, b) and α2 (c, d) chains were not detected at this stage. Laminin α3A (e-f) and α3B (g-h) chains were present but diminished in the airway basement membrane of Lamc2-/- (e, g) compared to littermate control (f, h) lungs. Laminin α4 (i-j), α5 (k-l), and γ1 (m-n) chains were present and similar in Lamc2-/- (i, k, m) and littermate control (j, l, n) lungs. Laminin γ2 is absent in Lamc2-/- (o) compared with littermate control (p) lungs. Original magnification 200×.

Back to article page