Figure 2

Intraperitoneal endotoxin application elicits alveolar macrophage expansion in mice. Mice were either left untreated (0 h time point) or were challenged intraperitoneally with a single dose of endotoxin (50 μg/mouse). At various time points post treatment, mice were sacrificed and subjected to bronchoalveolar lavage for determination of alveolar macrophage (black bars) and neutrophil (white bars) numbers, as indicated. Values are given as mean ± SEM of six mice per treatment group (96 h time point, n = 15). * indicates p < 0.01 versus control (0 h), + indicates p < 0.01 versus 96 h time point.