Figure 11
From: Ca2+-signaling in airway smooth muscle cells is altered in T-bet knock-out mice
Ca2+-content of intracellular Ca2+-pools. Ca2+-pools of ASMC in lung slices were depleted in the absence of external calcium by either opening ryanodine-receptor Ca2+-channels using caffeine or by inhibiting SERCA-pumps using CPA. In both cases, the Ca2+-increase following depletion of the Ca2+-pools was more pronounced in ASMC from T-bet KO-mice compared to wild -type mice indicating higher Ca2+-content in the asthma model (n = 20 lung slices from 5 different mice, * = P < 0.05).