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Figure 8 | Respiratory Research

Figure 8

From: Ca2+-signaling in airway smooth muscle cells is altered in T-bet knock-out mice

Figure 8

ACH-induced Ca2+-oscillations. (A) At ACH-concentrations of 10-10 to 10-7 M, the percentage of ASMC showing Ca2+-oscillations in lung slices from T-bet KO-mice (closed circles) was higher compared to wild-type mice (open circles, n = 20 to 26 lung slices from 5 to 6 different mice per concentration, P < 0.01). However, at 10-6 M ACH, only 19 % of the ASMC from T-bet KO-mice displayed Ca2+-oscillations while 81 % showed a Ca2+-plateau following the initial Ca2+-transient. (B) The frequency of the ACH-induced Ca2+-oscillations increased in a concentration dependent manner. No differences between ASMC from T-bet KO-mice and wild-type mice could be observed. Because of the low number of ASMC from T-bet KO-mice displaying Ca2+-oscillations at 10-6 M ACH, no frequency was calculated for this concentration.

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