Figure 10From: Airway smooth muscle relaxation results from a reduction in the frequency of Ca2+ oscillations induced by a cAMP-mediated inhibition of the IP3 receptorEffect of iberiotoxin on FSK-induced airway relaxation. (A) Airway contraction in response to MCh (200 nM), FSK (10 μM) and IbTX (50 nM). IbTX greatly enhanced the relaxation induced by FSK to fully relax the airway. Representative traces of 6 experiments from 3 mice. (B) Changes in intracellular Ca2+ signaling and (C) the frequency of Ca2+ oscillations induced by MCh (200 nM) and FSK (10 μM) followed by exposure to IbTX (50 nM). The frequency of the Ca2+ oscillations was further slowed by IbTX. Representative traces of 8 experiments from 5 mice.Back to article page