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Table 3 Minimal Clinically Important Difference (MCID) for the Clinical COPD Questionnaire (CCQ) by criterion referencing. Differences between baseline (Day 42) CCQ scores are grouped according to major health events during 12-month follow-up. Unpaired-sample t-tests were used for total CCQ scores and for symptom and functional domains, with equal variances assumed; the Mann-Whitney U test was used for the mental domain.

From: Health status measurement in COPD: the minimal clinically important difference of the clinical COPD questionnaire

CCQ score category

Score difference

 

Mean

95% confidence interval

p value

Death (n = 25) or survival (n = 143)

   

Total

-0.80

-1.23, -0.37

<0.001*

Symptoms

-0.62

-1.13, -0.12

0.015*

Function

-1.32

-1.90, -0.74

<0.001*

Mental

0.5§

 

0.211

Rehospitalization (n = 56) or not (n = 112)

   

Total

-0.18

-0.52, 0.16

0.290

Symptoms

-0.07

-0.46–0.31

0.706

Function

-0.47

-0.93, -0.007

0.047*

Mental

 

0.505

Death/rehospitalization (n = 70) versus survival/no rehospitalization (n = 98)

   

Total

-0.39

-0.71, -0.07

0.017*

Symptoms

-0.27

-0.63, 0.10

0.153

Function

-0.77

-1.19, -0.34

0.001*

Mental

 

0.987

  1. * Statistically significant (2-tailed): p < 0.05. § Difference in median scores
  2. COPD = chronic obstructive pulmonary disease.