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Figure 6 | Respiratory Research

Figure 6

From: Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse

Figure 6

5-HT-induced reduction of bronchial luminal area (bronchoconstriction) in OCT-deficient mice and sensitivity of this response to corticosterone. (A, B) Wild-type FVB mice (OCT1-3+/+), OCT1/2-/- mice and OCT3-/- mice exhibit no differences in their response to 5-HT (10-6 M). The numbers in parentheses refer to the numbers of bronchi/number of lungs from which they were taken. (C, D) In wild-type and OCT1/2-/- mice, but not in OCT3-/- mice, the bronchoconstriction in response to 5-HT is significantly reduced by corticosterone (Cs, 10-6 M). Panel (D) depicts the bronchoconstrictor response to 5-HT (10-6 M, 1 min after administration) in the presence of corticosterone (10-6 M), as compared to the response to 5-HT alone (set as 100%). **p < 0.01, Mann-Whitney U-test.

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Respiratory Research

ISSN: 1465-993X

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