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Table 2 Prevalence of genotypes according to COPD phenotype (GOLD stage II or higher; FEV1/VC<70%, FEV1 <80% predicted).

From: Decorin and TGF-β 1 polymorphisms and development of COPD in a general population

SNP

 

No COPD N (%)

COPD N (%)

P value df = 2

SNP

 

No COPD N (%)

COPD N (%)

P value df = 2

TGF-β1

GG

584 (52)

106 (58)

0.541

Decorin

AA

878 (76)

131 (76)

0.913

rs1800469

GA

474 (40)

67 (36)

 

rs741212

AG

242 (22)

43 (22)

 
 

AA

87 (8)

10 (6)

  

GG

15 (2)

4 (2)

 

TGF-β1

AA

382 (36)

75 (44)

0.297

Decorin

AA

614 (55)

102 (55)

0.949

rs1982073

AG

533 (49)

72 (42)

 

rs516115

AG

431 (38)

65 (38)

 
 

GG

156 (15)

23 (14)

  

GG

79 (7)

15 (7)

 

TGF-β1

GG

771 (69)

103 (56)

0.001

Decorin

GG

863 (88)

136 (89)

0.733

rs6957

GA

327 (29)

71 (39)

 

rs3138241

GA

114 (12)

10 (11)

 
 

AA

30 (2)

10 (5)

  

AA

3 (0)

1 (1)

 

Decorin

CC

996 (87)

170 (91)

0.217

Decorin

AA

1079 (94)

173 (93)

0.507

rs11106030

CA

142 (12)

8 (8)

 

rs1803343

AG

69 (6)

13 (7)

 
 

AA

4 (1)

1 (1)

  

GG

0 (0)

0 (0)

 
  1. Abbreviations: COPD, Chronic Obstructive Pulmonary Disease; FEV1, forced expiratory volume in 1 second; VC, vital capacity; TGF-β 1 , transforming growth factor-β1; df, degrees of freedom