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Table 2 Odds ratios (OR) and 95% confidence intervals (95% CI) for the association between single ADAM33 polymorphisms and asthma and BHR in the case-control population (age 9–11) and in the cohort study population assessed at age ten for asthma and age seven for BHR.

From: The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations

 

Asthma

BHR1

Asthma and BHR2

SNP

case-control study

cohort study

pooled

case-control study

cohort study

case-control study

F+1

0.92 (0.72–1.17)

p = 0.502

0.94 (0.58–1.52)

p = 0.795

0.92 (0.74–1.15)

p = 0.478

1.27 (0.96–1.69)

p = 0.095

1.01 (0.63–1.61)

p = 0.962

1.61 (0.90–2.88)

p = 0.105

M+1

0.86 (0.65–1.13)

p = 0.269

0.94 (0.53–1.65)

p = 0.819

0.89 (0.70–1.14)

p = 0.351

1.18 (0.88–1.59)

p = 0.274

1.03 (0.61–1.74)

p = 0.919

1.46 (0.84–2.54)

p = 0.177

S1

1.23 (0.90–1.69)

p = 0.201

1.16 (0.64–2.10)

p = 0.635

1.20 (0.90–1.58)

p = 0.210

1.27 (0.90–1.81)

p = 0.175

1.19 (0.67–2.14)

p = 0.552

1.10 (0.54–2.25)

p = 0.789

S2

0.99 (0.78–1.26)

p = 0.949

0.97 (0.60–1.56)

p = 0.893

0.99 (0.80–1.22)

p = 0.908

1.29 (0.98–1.69)

p = 0.073

1.00 (0.63–1.59)

p = 0.989

1.72 (0.99–3.00)

p = 0.052

ST+4

1.04 (0.81–1.34)

p = 0.766

1.31 (0.79–2.18)

p = 0.292

1.10 (0.87–1.37)

p = 0.432

0.99 (0.74–1.32)

p = 0.956

1.08 (0.67–1.74)

p = 0.762

1.22 (0.69–2.18)

p = 0.490

ST+5

0.94 (0.73–1.22)

p = 0.649

0.80 (0.48–1.33)

p = 0.384

0.89 (0.71–1.12)

p = 0.338

0.95 (0.71–1.28)

p = 0.748

1.20 (0.71–2.00)

p = 0.495

0.91 (0.51–1.60)

p = 0.731

ST+7

1.11 (0.86–1.42)

p = 0.428

1.16 (0.71–1.89)

p = 0.549

1.10 (0.88–1.38)

p = 0.384

1.20 (0.90–1.59)

p = 0.209

1.15 (0.72–1.84)

p = 0.562

0.96 (0.55–1.70)

p = 0.901

T1

0.96 (0.74–1.25)

p = 0.762

0.92 (0.53–1.60)

p = 0.764

0.97 (0.76–1.23)

p = 0.804

1.20 (0.90–1.61)

p = 0.213

1.12 (0.67–1.88)

p = 0.662

1.50 (0.87–2.59)

p = 0.141

T2

0.95 (0.73–1.24)

p = 0.711

0.88 (0.50–1.55)

p = 0.666

0.96 (0.76–1.22)

p = 0.731

1.21 (0.91–1.62)

p = 0.196

1.14 (0.68–1.91)

p = 0.622

1.51 (0.88–2.61)

p = 0.134

V4

1.22 (0.95–1.55)

p = 0.115

0.82 (0.51–1.34)

p = 0.439

1.11 (0.90–1.38)

p = 0.329

1.13 (0.85–1.49)

p = 0.402

1.13 (0.71–1.78)

p = 0.608

1.31 (0.76–2.26)

p = 0.332

  1. 1No pooled analysis because of different techniques of BHR assessment in the case-control study and in the cohort study
  2. 2 No analysis in the cohort study because of low number of cases