Skip to main content

Table 5 Estimated haplotype frequencies and associations with asthma in case control and cohort populations

From: The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations

 

Haplotype

Study population1)

Haplotype frequencies in the cases

Haplotype frequencies in the controls

Odds Ratio and Confidence intervals2)

p-value of χ2-Test

H1

G-G-G-A-T-G-T-C

all

30.35%

32.21%

0.92(0.78–1.08)

0.293

  

ccs

30.90%

31.56%

0.97(0.81–1.15)

0.735

  

coh

30.03%

34.02%

0.83(0.58–1.19)

0.317

H2

G-G-G-C-C-G-T-C

all

17.02%

16.69%

1.02(0.84–1.25)

0.804

  

ccs

16.77%

16.85%

0.99(0.80–1.24)

0.939

  

coh

16.93%

16.32%

1.04(0.67–1.63)

0.847

H3

A-G-C-A-C-G-C-C

all

12.98%

14.08%

0.91(0.73–1.13)

0.402

  

ccs

13.60%

14.85%

0.90(0.71–1.15)

0.406

  

coh

10.33%

12.04%

0.84(0.49–1.45)

0.531

H4

G-G-G-C-C-G-T-G

all

12.96%

10.44%

1.28(1.02–1.60)

0.033

  

ccs

13.15%

10.65%

1.27(0.99–1.64)

0.063

  

coh

11.43%

9.85%

1.18(0.70–2.00)

0.528

H5

A-A-C-A-T-A-T-G

all

8.35%

7.69%

1.09(0.83–1.43)

0.517

  

ccs

8.62%

7.16%

1.22(0.90–1.66)

0.191

  

coh

7.18%

9.07%

0.78(0.41–1.46)

0.430

H6

A-G-G-C-C-A-T-C

all

6.70%

6.54%

1.03(0.76–1.38)

0.867

  

ccs

6.17%

6.67%

0.92(0.65–1.30)

0.638

  

coh

8.99%

6.19%

1.50(0.82–2.72)

0.184

  1. 1) All = case control study and cohort study population pooled, ccs = case control study (n = 358 cases/n = 1198 controls), coh = cohort study (n = 82 cases/n = 464 controls); children without haplotype information were excluded
  2. 2) Odds Ratios were calculated as one haplotype vs. all others