Figure 8From: Hypoxic vasoconstriction of partial muscular intra-acinar pulmonary arteries in murine precision cut lung slicesSpecific requirement of mitochondrial complex III, but not of complex IV, for HPV. Videomorphometric analysis of HPV was performed in absence or presence of the complex III inhibitor antimycin A (A) and of the complex IV inhibitor NaN3 (B), respectively. (A) Antimycin A induced distinct vasodilation during hypoxic exposure whereas the response to U46619 was unaffected. (B) NaN3 inhibited both HPV and U46619-induced vasoconstriction. Data are presented as means ± SEM. *p = 0.05, ** p = 0.01, n.s. = not significant.Back to article page