Figure 8
Specific requirement of mitochondrial complex III, but not of complex IV, for HPV. Videomorphometric analysis of HPV was performed in absence or presence of the complex III inhibitor antimycin A (A) and of the complex IV inhibitor NaN3 (B), respectively. (A) Antimycin A induced distinct vasodilation during hypoxic exposure whereas the response to U46619 was unaffected. (B) NaN3 inhibited both HPV and U46619-induced vasoconstriction. Data are presented as means ± SEM. *p = 0.05, ** p = 0.01, n.s. = not significant.