Table 2 Results of the high dose salbutamol study (study 1)
Treatment | Placebo | Formoterol |
|---|---|---|
Pre-challenge FEV1 (L) (SD) | 2.55 (0.75) | 2.57 (0.72) |
Post challenge FEV1 (L) (SD) | 1.92 (0.59) | 2.00 (0.51) |
PD20 methacholine (mg) (geometric mean, 95% CI) | 0.08 (0.03, 0.22) | 0.10 (0.04, 0.25) |
AUC salbutamol (%.time) (SD) | 412 (140) | 339 (201) |
Difference: paired t-test (95% CI) | 73 (-4, 149) p = 0.06 | |
Difference: covariate analysis (placebo-formoterol) (least squares means, 95% CI) | 63 (22, 105) p = 0.008 | |
Post-salbutamol FEV1 at 20 mins (L) (SD) | 2.79 (0.86) | 2.67 (0.84) |
Difference: paired t-test (95% CI) | 0.12 (0.03, 0.20) p = 0.008 | |
Difference: covariate analysis (placebo-formoterol) (least squares means, 95% CI) | 0.12 (0.06, 0.19) p = 0.003 | |