From: Invasive and noninvasive methods for studying pulmonary function in mice
pros | cons |
---|---|
• minimal restraint of the animal | • enhanced pause as an empirically derived value with unclear physiological relevance |
 | • influenced by a number of factors unrelated to bronchoconstriction |
 | • potential to overestimate or underestimate the real degree of airway responsiveness |
 | • data need to be confirmed by invasive methodology |