In vitro metabolism of beclomethasone dipropionate, budesonide, ciclesonide, and fluticasone propionate in human lung precision-cut tissue slices

Table 3 Relative drug amounts [% of total UV areas] in medium

	Incubation time [h]	Parent compound	Active compound	Inactive metabolite
*Beclomethasone*	2	60.9 ± 7.0	35.7 ± 6.4	3.4 ± 0.8
*Dipropionate* ¹	6	19.1 ± 8.3	53.5 ± 4.3	27.3 ± 4.7
	24	-	8.4 ± 5.3	91.6 ± 5.3
*Ciclesonide*	2	94.9 ± 1.3	5.1 ± 1.3	-
	6	83.2 ± 5.5	16.8 ± 5.5	-
	24	37.4 ± 7.8	62.6 ± 7.8	-

Data are presented as mean ± standard deviation (n = 9).
No metabolites of Bud and FP were detected in medium.
¹The active compound of BDP may be overestimated as inactive 21-BMP may be included.

ISSN: 1465-993X