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Table 4 Relative drug amounts [% of total UV areas] in human lung tissue slices

From: In vitro metabolism of beclomethasone dipropionate, budesonide, ciclesonide, and fluticasone propionate in human lung precision-cut tissue slices

 

Incubation time [h]

Parent compound

Active compound

Fatty acid esters

Inactive metabolite

Beclomethasone

2

21.4 ± 9.8

72.1 ± 9.2

2.9 ± 1.1

3.6 ± 0.8

dipropionate 2

6

9.2 ± 7.9

66.6 ± 17.7

4.4 ± 2.6

19.8 ± 10.0

 

24

-

26.6 ± 16.8

8.5 ± 7.8

64.9 ± 14.4

Budesonide 1

2

72.2 ± 10.8

27.8 ± 10.8

-

 

6

64.9 ± 12.0

35.1 ± 12.0

-

 

24

53.6 ± 11.5

46.4 ± 11.5

-

Ciclesonide

2

85.0 ± 3.4

9.9 ± 1.4

5.1 ± 2.1

-

 

6

73.5 ± 4.7

17.9 ± 1.5

8.6 ± 4.1

-

 

24

40.0 ± 7.6

31.5 ± 2.4

28.5 ± 8.8

-

Fluticasone 1

2

100 ± 0.0

-

-

propionate

6

100 ± 0.0

-

-

 

24

100 ± 0.0

-

-

  1. Data are presented as mean ± standard deviation (n = 9).
  2. 1Parent and active compound.
  3. 2The active compound of BDP may be overestimated as inactive 21-BMP may be included.