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Table 4 Difference in FEV1 for a one SD or quintile increase in minerals and other nutrients

From: A multivariate analysis of serum nutrient levels and lung function

Nutrient

Model as

Model 1*

Model 2†

Model 3‡

  

β coeff

95% CI

β coeff

95% CI

β coeff

95% CI

Normalised calcium (mmol/l)

≤ 2.23

reference

 

reference

 

reference

 
 

2.24 – 2.29

38.9

11.9 to 65.9

41.2

14.8 to 67.5

36.5

10.3 to 62.7

 

2.30 – 2.33

68.5

43.9 to 93.0

71.8

47.1 to 96.5

64.1

39.5 to 88.6

 

2.34 – 2.39

50.3

19.6 to 80.9

58.5

28.3 to 88.6

50.3

19.6 to 80.9

 

≥ 2.4

25.8

-6.5 to 58.0

39.4

7.1 to 72.5

29.0

-1.0 to 52.7

       

p = 0.001

Chloride (mmol/L)

Per SD change

27.2

17.9 to 36.5

35.6

22.8 to 48.5

40.5

28.4 to 52.7

       

p < 0.001

Iron (μmol/L)

≤ 10.21

reference

 

reference

 

reference

 
 

10.22 – 13.43

33.6

8.9 to 58.3

37.5

11.5 to 63.5

23.3

-3.6 to 50.2

 

13.44 – 16.48

68.0

43.1 to 92.8

72.2

46.1 to 98.2

51.0

23.9 to 78.2

 

16.49 – 20.6

51.8

29.1 to 74.6

58.0

35.5 to 80.5

35.2

12.9 to 57.6

 

≥ 20.61

70.8

40.1 to 101.6

77.8

45.5 to 110.0

54.2

21.0 to 86.4

       

p = 0.0054

TIBC (μmol/L)

≤ 54.98

reference

     
 

54.99 – 60.36

12.8

-13.0 to 38.6

    
 

60.37 – 65.19

19.1

-2.9 to 41.0

    
 

65.20 – 71.82

3.1

-24.9 to 31.0

    
 

≥ 71.83

-25.4

-52.7 to 1.9

    

Transferrin saturation (%)

Per SD change

24.2

14.2 to 34.2

    

Ferritin (μmol/L)

Per SD change

3.4

-5.1 to 12.0

    

Red blood cell folate (nmol/L)

≤ 256.1 256.2 – 326.3

reference 40.4

16.9 to 63.8

reference 41.1

16.8 to 65.3

reference 27.4

3.9 to 51.0

 

326.4 – 407.9

33.3

4.5 to 62.1

29.7

1.0 to 58.4

9.3

-18.2 to 36.8

 

408.0 – 555.2

43.3

16.9 to 69.7

45.5

17.1 to 73.9

14.1

-13.9 to 42.2

 

≥ 555.3

36.3

8.0 to 64.6

34.3

2.8 to 65.8

-13.2

-45.1 to 18.7

       

p = 0.0207

Potassium (mmol/l)

Per SD change

-10.7

-18.2 to -3.1

-15.6

-22.1 to -9.0

-21.2

-28.3 to -14.1

       

p < 0.001

Sodium (mmol/l)

Per SD change

6.6

-0.9 to 14.0

-10.1

-21.0 to 0.72

-13.0

-24.1 to -2.0

       

p = 0.022

Total Protein (g/L)

Per SD change

-17.2

-28.5 to -5.9

    
  1. * Model 1- Adjusted for age, sex, height, smoking (status and packyears), BMI, race/ethnicity
  2. † Model 2- Adjusted for covariates listed under Model 1, as well as for all nutrients with statistically significant associations with lung function in a mutually adjusted model. Number of participants in model = 14120
  3. ‡ Model 3- Adjusted for all covariates and nutrients in Model 1 & 2 and additionally adjusted for minerals and other nutrients found to be significantly associated with lung function (model 2) in Table 3. Number of participants in model = 12657
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Respiratory Research

ISSN: 1465-993X

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