Figure 5

Hypothetical model of nuclear translocation of STAT3. (A) When stimulating cells from wildtypes (Q551) with IL-4, a potential inhibitor does not bind to STAT3 and nuclear translocation takes place. (B) When stimulating wildtypes (Q551) with IL-13, a potential inhibitor is able to interact with STAT3 and prevents it from being translocated. (C) When stimulating variants R551 with IL-4, the inhibitor is able to interact and prevent the STAT3 translocation. (D) When stimulating the variants with IL-13. STAT3 is translocated STAT = signal transducer and activator of transcription.