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Table 1 SLPI and elafin characteristics

From: The role of secretory leukocyte proteinase inhibitor and elafin (elastase-specific inhibitor/skin-derived antileukoprotease) as alarm antiproteinases in inflammatory lung disease

Property

SLPI

ESI/elafin/SKALP

Family name

Four disulfide core

Four disulfide core/trappin

Molecular mass (kDa)

11.7

9.8

Spectrum of protease inhibition

HNE, trypsin, chymotrypsin, tryptase,

HNE, pig pancreatic elastase, proteinase-3

 

chymase, cathepsin G

 

Cell and tissue distribution in lung

Tracheal, bronchial, Clara, alveolar type II cells,

Tracheal, Clara, alveolar type II cells,

 

monocytes, alveolar macrophages, neutrophils

alveolar macrophages

Regulatory stimuli

LPS, IL-1, TNF, HNE

IL-1, TNF, HNE

Biological properties

Antimicrobial, antiviral, anti-HNE, inhibition of

Antimicrobial, anti-HNE

 

monocyte inflammatory potential

 

Gene therapy potential

Currently being explored

Adenovirus-elafin protects against lung injury

  

(rodent model)

  1. HNE = neutrophil elastase.