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Table 3 Potential modulation of SP-D function

From: Surfactant protein-D and pulmonary host defense

Altered patterns of oligomerization

   Liberation of trimeric subunits secondary to proteolytic degradation

   Self-aggregation

Modifications of the CRD

   Proteolytic degradation

   Oxidative modification

   Local pH and calcium concentration

Competing ligands

   LPS

   Microorganisms

Host lectins with overlapping specificity

   Mannose receptor

   Other collectins (SP-A, mannose-binding lectin)

   Non C-type lectins (such as ficolins)

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Respiratory Research

ISSN: 1465-993X

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