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Table 1 Candidate genes that have been associated with COPD in case–control studies

From: The genetics of chronic obstructive pulmonary disease

PI MZα1-antitrypsin deficiency

Tumour necrosis factor α

Microsomal epoxide hydrolase

Glutathione S1-transferase

Heme Oxygenase-1

Taq-1 polymorphism of α1-antitrypsin

Alpha1-antichymotrypsin

Vitamin D binding protein

ABO Blood Group

ABH Secretor Status

Cystic fibrosis transmembrane regulator

HLA

Cytochrome P450

  1. For most of these loci, some studies have supported a significant association while other studies have refuted the association. Candidate genes for which there is the strongest supporting evidence are shown in bold.