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Supplementary Table 1 Main functions: surfactant delivery and epithelial repair

From: Alveolar epithelial type II cell: defender of the alveolus revisited

Function/product

Functional significance

Reference

Surfactant

  

   Synthesis

  

   Components of surfactant

  

Phospholipids

Surface activity

[186]

Surfactant proteins

  

A

Tubular myelin formation

[71,187,188]

 

Defence

[33]

B

Absorption of lipid to monolayer

[71,189]

C

 

[86]

D

Defence

[34,190]

   Components secreted together with surfactant

  

Lysozyme

Defence

[35,191]

Plasmalogens

Protection against oxidation

[192]

Cathepsin H

  

   Maturation

  

Intracellular cathepsin H

Processing of SP-B

[194]

 

Processing of SP-C

[50]

   Secretion

  

   Signal receptors

  

β-adrenergic receptors

 

[195,196]

P1 purinoreceptors

 

[197,198]

P2Y purinoreceptors

 

[198,199]

   Components of exocytosis apparatus

  

Microtubules

 

[65]

Actin

 

[66]

Annexin II

 

[200]

Annexin IV

 

[201]

Annexin VII (= Synexin)

 

[202,203]

   Extracellular transformation

  

α1-antitrypsin

 

[2048]

Convertase

Conversion of lipid monolayer into vesicles

[88,89,205]

   Recycling

  

Receptor of SP-A

 

[206]

Lamellar body lysosomal enzymes

  

Alkaline phosphatase

Marker of type II cells

[207]

α-glucosidase

 

[208]

α-mannose

 

[208]

Alveolar epithelial repair

  

   Proliferation

  

Cyclin A

 

[209]

Cyclins D1, D2

Proliferation, differentiation

[210]

Cyclin dependent phosphokinases

Proliferation, differentiation

[210]

PTHRP

Inhibition of proliferation

[211]

Calmodulin

Proliferation, differentiation

[212,213]

Insulin-like growth factor (IGF)-binding protein2

G1-arrest

[214]

   Differentiation

  

Retinoic acid receptor

Inhibition of differentiation

[215]

Aminopeptidase N

 

[216]

   Apoptosis

  

CD95 (receptor of Fas-ligand)

 

[134]

Fas-ligand

 

[138]

Bax

Pro-apoptotic peptide

[217]

Bcl-2

Anti-apoptotic peptide

[138]

Caspase-3

Execution caspase

[138]