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Figure 1 | Respiratory Research

Figure 1

From: The molecular basis of resistance to isoniazid, rifampin, and pyrazinamide in Mycobacterium tuberculosis

Figure 1

Previously demonstrated and proposed sites of action of isoniazid (INH), pyrazinamide (PZA), and rifampin (RMP) on the M tuberculosis cell. INH inhibits the synthesis of mycolic acids [19,20], PZA inhibits the synthesis of short-chain, fatty-acid precursors [32], and RMP inhibits transcription by binding to the β-subunit of RNA polymerase [28]. This figure is adapted in part from Parsons et al [40].

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