From: Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene
Control subjects | PRISm | COPD | |
---|---|---|---|
n | 4388 | 1257 | 3690 |
Age | 56.7 (8.4)* | 57.2 (8.2) | 63.4 (8.5)* |
Sex (% Male) | 52.9* | 46.1 | 55.6* |
African American | 41.2 | 43.1 | 22.7* |
Current smoker | 59.7* | 63.8 | 40.7* |
Pack-years | 37.2 (20.2)* | 42.7 (24.2) | 53.0 (27.5)* |
Body Mass Index | 28.9 (5.8)* | 31.8 (7.3) | 28.1 (6.3)* |
FEV1% predicted | 97.5 (11.5)* | 70.2 (8.4) | 50.2 (18.0)* |
FVC% predicted | 96.6 (11.9)* | 71.5 (9.1) | 76.3 (17.3)* |
FEV1/FVC | 0.79 (0.05)* | 0.77 (0.05) | 0.50 (0.13)* |
Bronchodilator Responsiveness† | 10.0* | 13.7 | 36.6* |
Total Lung CapacityCT% predicted | 92.3 (14.6)* | 79.9 (13.5) | 101.5 (17.1)* |
Segmental wall area percentage | 60.1 (2.9)* | 62.5 (3.1) | 62.9 (3.1)* |
Percent emphysema (% LAA-950insp) | 2.0 (2.5)* | 1.4 (2.5) | 13.0 (12.8)* |
Percent gas trapping (% LAA-856exp) | 11.0 (9.7) | 10.4 (9.1) | 39.2 (20.8)* |
Pi10 | 3.65 (0.11)* | 3.73 (0.14) | 3.72 (0.14)* |
6 minute walk distance (feet) | 1491.5 (350.7)* | 1266.6 (366.9) | 1174.8 (397.0)* |
MMRC‡ Dyspnea score | 0.8 (1.2)* | 1.5 (1.5) | 2.1 (1.4)* |
Resting O2 saturation | 97.1 (2.0)* | 96.5 (2.5) | 94.7 (3.6)* |
Chronic bronchitis | 12.6* | 17.8 | 28.2* |
Short acting beta-agonist use | 12.0* | 28.1 | 65.7* |
Long acting beta-agonist use | 4.4* | 13.3 | 49.1* |
Inhaled corticosteroid use | 5.5* | 16.4 | 51.2* |
Oral corticosteroid use | 0.5* | 2 | 5.9* |
Congestive heart failure | 1.3* | 4.6 | 5.4 |
Coronary artery disease | 7.5* | 13.5 | 16.5* |
Diabetes mellitus | 11.6* | 21.6 | 13.1* |
Hypertension | 36.3* | 49.1 | 50.6 |
Hyperlipidemia | 34.3* | 42.5 | 41.4 |
History of blood clot | 2.8* | 5.2 | 5.7 |
Peripheral vascular disease | 1.3* | 2.7 | 3.4 |
History of stroke | 1.6* | 3.5 | 3.6 |
Gastrointestinal reflux disease | 20.3* | 25.9 | 30.3* |
History of compression fracture | 3.4* | 5.4 | 6.2 |
Currently employed | 37.3* | 28.9 | 25.3* |
Physician-diagnosed asthma | 11.4* | 21.1 | 24.6* |