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Figure 6 | Respiratory Research

Figure 6

From: Adjuvant-dependent regulation of interleukin-17 expressing γδ T cells and inhibition of Th2 responses in allergic airways disease

Figure 6

OVA/CFA sensitized mice receiving a γδ TCR stimulatory antibody, have reduced airway eosinophilia and AHR. OVA/CFA sensitized mice were IV injected with a γδ TCR (UC7-13D5) stimulatory antibody or isotype control before airway challenge. The mean (A) total cell counts and (B) frequencies of macrophages, eosinophils, neutrophils and lymphocytes (+SEM) are shown for 5 total mice per group from 2 independent experiments. (C) Total lung resistance and elastance were assessed 24 h after the last airway OVA challenge. Mean (±SEM) respiratory system resistance and elastance to increasing concentrations of methacholine are shown. (A-C) Unpaired, two-tailed t-test. *p < 0.05, ns = not significant.

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