Table 1 Demographics of the study population and biologic samples for analysis of aging signature gene expression in the small airway epithelium 1
From: Smoking accelerates aging of the small airway epithelium
Parameter | Healthy nonsmokers | Healthy smokers | p value6 |
|---|---|---|---|
n | 29 | 29 | Â |
Gender (M/F) | 16/13 | 22/7 | Â |
Age (yr) | 38.0 ± 12.4 | 38.8 ± 10.1 | >0.8 |
Race (B/W/O)2 | 10/8/11 | 13/8/8 | Â |
Smoking history (pack-yr) | 0 | 17.8 ± 8.4 |  |
Urine nicotine (ng/ml) | negative | 1657 ± 1527 |  |
Urine cotinine (ng/ml) | negative | 1929 ± 1060 |  |
Pulmonary function parameters3 | Â | Â | Â |
FVC | 106.9 ± 12.1 | 111.1 ± 11.6 | >0.17 |
FEV1 | 106.3 ± 12.2 | 109.4 ± 13.1 | >0.35 |
FEV1/FVC | 82.8 ± 4.9 | 81.0 ± 4.3 | >0.13 |
TLC | 99.7 ± 17.3 | 97.6 ± 14.1 | >0.6 |
DLCO | 90.4 ± 9.6 | 86.0 ± 5.4 | <0.04 |
Body mass index (BMI) | 26.4 ± 5.3 | 27.8 ± 4.8 | >0.3 |
Epithelial cells4 | Â | Â | Â |
% epithelial cells | 98.9 ± 0.9 | 99.2 ± 0.8 | >0.2 |
% inflammatory cells | 1.0 ± 0.8 | 0.8 ± 0.8 | >0.2 |
Differential cell count5 | Â | Â | Â |
Ciliated (%) | 71.3 ± 5.3 | 62.9 ± 6.9 | <0.00001 |
Secretory (%) | 10.0 ± 4.5 | 12.3 ± 6.4 | >0.12 |
Basal (%) | 9.5 ± 6.6 | 9.6 ± 6.6 | >0.96 |
Undifferentiated columnar (%) | 8.2 ± 4.9 | 14.5 ± 8.2 | <0.001 |