Nebulized perflubron and carbon dioxide rapidly dilate constricted airways in an ovine model of allergic asthma

Respiratory Research

Table 1 Characterization of nebulized perflubron using the Sidestream (venturi closed)

		Nebulized perflubron			Aerosol size
Sidestreamventuri CLOSED	Nebulizer flow rate L/min	Inhaled perflubron aerosol 1 minute mg	Inhaled perflubron Vapor 1 minute mg	Inhaled Total perflubron aerosol + vapor 1 minute mg/min	MMAD μm	GSD
Exp#1	8.5	208	392	600	1.1	2.4
Exp#2	8.5	198	399	597	1.1	2.6

Nebulized perflubron was characterized in two separate experiments (exp#1 and exp#2) using compressed gas flow rate of 8.5 L/min through a Sidestream nebulizer with active venturi closed. Nebulized perflubron liquid was determined to partition into aerosol and vapour states, with the vapour being the predominant physical form (means: 395 mg/min vapour vs 203 mg/min aerosol). The droplet size of the aerosolized perflubron component was further examined and fractionated using a Marple 298X cascade impactor. The nebulized perflubron aerosol distribution curve showed near log normal symmetry (see normative distribution, Figure 4) having a Mass Median Aerodynamic Diameter (MMAD) of 1.1 um, and a Geometric Standard Deviation (GSD) of 2.5.

ISSN: 1465-993X