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Table 3 Bacterial loads and associated airway inflammation in single and mixed-potentially pathogenic microorganisms (PPMs) colonised samples

From: Inflammatory thresholds and the species-specific effects of colonising bacteria in stable chronic obstructive pulmonary disease

 

HI

SP

MC

mixed-PPM

p-value†

 

n = 21

n = 21

n = 7

n = 15

 

Mean (SD) Bacterial load

106.2(1.2)

106.5(1.1)

108.6(1.8)

108.5(1.5)

<0.001

Median (IQR) CXCL8 (ng.ml -1 )

179

90

219

127

0.003

(95-453)

(50-194)

(140-309)

(67-677)

 

Median (IQR) IL-1β (ng.ml -1 )

4.8

0.9

1.4

1.6

<0.001

(0.8-7.8)

(0.6-1.5)

(0.4-7.2)

(0.9-6.7)

 

Median (IQR) MPO (μg.ml -1 )

30.1

27.2

23.6

29.1

0.011

(26.4-38.9)

(13.3-37.6)

(18.1-35.6)

(11.1-51.0)

 
  1. Definitions: HI = Haemophilus influenzae; SP = Streptococcus pneumoniae; MC = Moraxella catarrhalis; PPM = potentially pathogenic microorganisms.
  2. †p-value refers to One-way ANOVA or Kruskal-Wallis between the single PPMs and mixed-PPM samples.
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Respiratory Research

ISSN: 1465-993X

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