Figure 4

Oseltamivir treatment reduces disease severity in the aged mice following influenza infection. A. Body weight change in the aged mice with (square) and without (triangular) oseltamivir treatment following influenza infection. B. Viral load (PFU/g of lung tissue) in the aged mice with (solid column) and without (open column) oseltamivir treatment following influenza infection. C. Infiltration index in the aged mice with (solid column) and without (open column) oseltamivir treatment following influenza infection. Five oseltamivir-treated and 5 untreated aged mice were used for each time-point. All error bars represent standard errors. *p < 0.05, **p < 0.01 by Student t-test. D-F. Representative H&E images of lung sections of the aged mice without oseltamivir treatment at 6 (D), 12 (E), and 21 (F) dpi. G-I. Representative H&E images of lung sections of the aged mice with oseltamivir treatment at 6 (G), 12 (H), and 21 (I) dpi. Scale bar: 500 μm.