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Table 2 Assessment of cardiac function by echocardiography

From: Effects of exercise training on pulmonary vessel muscularization and right ventricular function in an animal model of COPD

 

Fresh air

Cigarette smoke

Significance

 

Sedentary

Exercise

Sedentary

Exercise

F1

F2

I

Heart Rate (stroke/min)

485 ± 30

443 ± 52

444 ± 35

458 ± 33

.27

.26

.024

FS (%)

33.4 ± 3.6

36.5 ± 3.7

35.0 ± 4.0

36.8 ± 6.2

.51

.075

(.63)

LV S’ (mm/s)

21.2 ± 3.4

21.6 ± 3.0

19.6 ± 3.6

19.7 ± 3.8

.11

.84

(.93)

LV E’ (mm/s)

31.3 ± 3.8

33.0 ± 4.3

29.6 ± 6.8

30.2 ± 3.9

.16

.50

(.73)

IVRT (ms)

16.4 ± 1.4

14.1 ± 1.7

16.5 ± 1.6

15.9 ± 1.3

.074

.004

(.09)

TAPSE (mm)

.71 ± .0.04

.82 ± .11

.42 ± .06

.75 ± .12

.008

<.001

(.11)

RV S’ (mm/s)

22.5 ± 5.1

22.0 ± 5.6

20.4 ± 4.9

23.4 ± 3.7

.56

.004

(.078)

RV E’ (mm/s)

31.2 ± 8.3

29.9 ± 6.3

29.15 ± 8.0

31.8 ± 5.1

.51

.007

(.78)

RV IVRT’/RR (%)

8.5 ± 2.3

4.5 ± 1.7

9.5 ± 2.0

6.3 ± 1.6

.058

<.001

(.43)

RV lateral wall thickness (mm)

1.53 ± .40

1.61 ± .34

1.57 ± .35

1.76 ± .31

.50

.33

(.74)

  1. Echocardiography performed on mice exposed to cigarette smoke or fresh air and subsequently put through exercise training or kept sedentary. HR: heart rate; FS: fractional shortening for left ventricle (LV); LV S’: LV Doppler tissue imaging (DTI) systolic velocity; LV E’: LV DTI early diastolic velocity; IVRT: isovolumic relaxation time; TAPSE: tricuspid annular systolic excursion; RV S’: right ventricle (RV) DTI systolic velocity; RV E’: RV DTI early systolic velocity; RV IVRT’/RR: isovolumic relaxation time derived from RV DTI. F1-column: p-value for main effect of smoke exposure; F2-column: p-value for main effect of exercise; I-column: p-values for interaction term between smoke exposure and exercise. 2-way ANOVA, interaction term removed if not significant (p-value for interaction term then presented in parenthesis). Data presented as mean ± SD.