Table 3 Clinical predictors of IPF vs. CTD-UIP diagnosis
| Â | Univariable OR (95% CI) | P value | Multivariable OR (95% CI) | P value |
|---|---|---|---|---|
Age at biopsy | 1.06 (1.03-1.09) | <0.0001 | 1.06 (1.02-1.08) | 0.0012 |
Gender (male risk) | 2.52 (1.44-4.49) | <0.0001 | 1.87 (0.95-3.7) | 0.07 |
Duration of symptoms prior to biopsy | 1.01 (0.99-1.02) | 0.27 | 1.01 (0.99-1.03) | 0.19 |
Positive autoimmune serology | 0.08 (0.04-0.15) | <0.0001 | 0.09 (0.04-0.17) | <0.0001 |
FEV1, % pred | 1.01 (0.99-1.03) | 0.17 | 1.03 (0.97-1.10) | 0.27 |
FVC, % pred | 1.00 (0.98-1.02) | 0.61 | 0.99 (0.92-1.07) | 0.73 |
DLCO, % pred | 1.01 (0.99-1.03) | 0.31 | 1.02 (0.99-1.05) | 0.15 |
TLC, % pred | 0.99 (0.98-1.02) | 0.74 | 0.98 (0.94-1.03) | 0.36 |
Initial HRCT pattern | Â | Â | Â | Â |
Probable UIP | 1.00 (0.42-2.27) | 0.98 | 0.79 (0.29-2.05) | 0.64 |
Probable NSIP or inconsistent with UIP | 0.40 (0.17-0.86) | 0.02 | 0.31 (0.11-0.76) | 0.01 |
Atypical findings on biopsy | 0.36 (0.19-0.69) | 0.003 | 0.56 (0.27-1.22) | 0.56 |