Table 5 Subgroup analysis of clinical predictors for death in CTD-UIP
| Â | Univariable HR (95% CI) | P value | Multivariable, HR (95% CI) | P value |
|---|---|---|---|---|
Age at biopsy | 1.06 (1.02-1.11) | 0.0031 | 1.05 (1.01-1.11) | 0.03 |
Gender (male risk) | 1.91 (0.83-4.34) | 0.13 | 1.05 (0.39-2.80) | 0.92 |
Smoking Hx | 4.24 (1.76-11.80) | 0.0010 | 2.74 (0.98-9.01) | 0.06 |
Duration of symptoms prior to biopsy | 1.00 (0.99-1.02) | 0.69 | 1.01 (0.98-1.03) | 0.60 |
GERD | 0.71 (0.31-1.60) | 0.41 | 0.64 (0.25-1.60) | 0.33 |
FEV1, % pred | 0.97 (0.95-0.99) | 0.04 | 0.99 (0.90-1.13) | 0.97 |
FVC, % pred | 0.98 (0.96-0.99) | 0.02 | 0.95 (0.92-0.98) | 0.01 |
DLCO, % pred | 0.95 (0.92-0.99) | 0.005 | 0.99 (0.95-1.03) | 0.58 |
TLC, % pred | 0.96 (0.93-0.99) | 0.01 | 0.99 (0.92-1.07) | 0.88 |
Initial HRCT pattern | Â | Â | Â | Â |
Probable UIP | 1.78 (0.46-11.67) | 0.44 | 2.06 (0.48-14.31) | 0.35 |
Probable NSIP or inconsistent with UIP | 2.34 (0.64-14.99) | 0.22 | 2.83 (0.71-19.10) | 0.15 |
Atypical findings on biopsy | 0.39 (0.11-1.02) | 0.06 | 0.68 (0.19-1.91) | 0.49 |