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Figure 2 | Respiratory Research

Figure 2

From: Cell surface marker profiling of human tracheal basal cells reveals distinct subpopulations, identifies MST1/MSP as a mitogenic signal, and identifies new biomarkers for lung squamous cell carcinomas

Figure 2

Conditions that support expansion of primary human tracheal basal cells maintain mucociliary differentiation activity. Expanded, primary P0 human tracheal basal cells were enzymatically removed from plastic dishes and grown as rat tracheal xenografts. After five weeks, mucociliary differentiation in xenografts was assessed morphologically by H/E staining of tissue sections (A, B, D-F). (A) Control transplanted rat tracheal xenograft not seeded with human basal cells. (C) FISH with a human-specific chromosome 3 centromeric probe to detect cells of human origin. Insets show magnified areas of positivity in xenografted epithelia (white), but not underlying stroma (green). Scale bars are 20 μm.

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