Table 2 Pharmacokinetic profile of PXS-4728A in rodents

Oral dose

6 mg.kg ⁻¹

10 mg.kg ⁻¹

Bioavailability (%)

55

92

Apparent concentration at curve maximum C_max (μg.ml⁻¹)

0.72

1.38

Time of maximal concentration T_max (hour)

0.83

0.25

Clearance CL (ml.kg.min⁻¹)

45

98

Intravenous dose

3 mg.kg ⁻¹

5 mg.kg ⁻¹

Apparent concentration at curve maximum C_max (μg.ml⁻¹)

4.21

1.6

Time of maximal concentration T_max (min)

0.03

0.03

Clearance CL (ml.kg.min⁻¹)

23

80

Apparent half-life, t_1/2 (h)

1.1

0.6