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Table 3 Genotype frequencies of HHIP and FAM13A SNPs and their association with COPD risk in COPD patients and controls in replication cohorts

From: Gene susceptibility identification in a longitudinal study confirms new loci in the development of chronic obstructive pulmonary disease and influences lung function decline

Gene

SNP

Position (NCBI)

Genotypes of SNPs

Rural replication cohort

Urban replication cohort

Subjects of all Cases and Controls

HWE p-value

GF(Cases/Contols)

P

OR(95% CI)

GF(Cases/Controls)

P

OR(95% CI)

GF(Cases/Controls)

P

OR(95% CI)

HHIP

rs11100865

145870597

G → A

         

0.229

   

GG

0.291/0.304

 

reference

0.297/0.380

 

reference

0.282/0.334

 

reference

 
   

AG

0.484/0.525

0.371

1.174(0.826-1.668)

0.475/0.421

0.031

1.375(1.029-1.838)

0.478/0.472

0.048

1.210(1.002-1.461)

 
   

AA

0.225/0.171

0.034

1.605(1.037-2.485)

0.228/0.199

0.079

1.373(0.964-1.957)

0.240/0.194

0.001

1.451(1.155-1.822)

 
 

rs12504628

145655774

T → C

         

0.314

   

TT

0.489/0.513

 

reference

0.518/0.477

 

reference

0.509/0.493

 

reference

 
   

CT

0.439/0.383

0.318

1.174(0.857-1.608)

0.379/0.412

0.083

0.785(0.597-1.032)

0.394/0.409

0.254

0.904(0.760-1.075)

 
   

CC

0.073/0.104

0.225

0.709(0.407-1.235)

0.104/0.112

0.119

0.705(0.454-1.095)

0.097/0.098

0.6

0.926(0.694-1.235)

 
 

rs13118928

145705839

A → G

         

0.875

   

AA

0.486/0.479

 

reference

0.535/0.504

 

reference

0.511/0.478

 

reference

 
   

AG

0.445/0.429

0.985

1.003(0.736-1.367)

0.391/0.396

0.273

0.858(0.653-1.128)

0.407/0.429

0.08

0.857(0.722-1.019)

 
   

GG

0.068/0.092

0.239

0.707(0.397-1.259)

0.073/0.100

0.044

0.606(0.373-0.987)

0.082/0.093

0.119

0.786(0.580-1.064)

 
 

rs7654947

145845180

T → C

         

0.370

   

TT

0.369/0.514

 

reference

0.351/0.309

 

reference

0.352/0.406

 

reference

 
   

CT

0.452/0.315

1.99E-05

2.049(1.473-2.848)

0.494/0.501

0.298

0.856(0.639-1.147)

0.472/0.413

0.001

1.334(1.121-1.612)

 
   

CC

0.179/0.171

0.032

1.579(1.040-2.396)

0.155/0.190

0.04

0.663(0.448-0.982)

0.176/0.182

0.305

1.131(0.894-1.432)

 

FAM13A

rs7671167

90103002

T → C

         

0.205

   

TT

0.288/0.232

 

reference

0.323/0.266

 

reference

0.312/0.247

 

reference

 
   

CT

0.503/0.452

0.467

0.873(0.604-1.260)

0.503/0.495

0.488

0.899(0.666-1.214)

0.495/0.466

0.116

0.855(0.703-1.040)

 
   

CC

0.209/0.316

0.002

0.508(0.333-0.774)

0.174/0.239

0.029

0.661(0.455-0.959)

0.193/0.288

8.71E-08

0.531(0.421-0.670)

 
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Respiratory Research

ISSN: 1465-993X

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