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Fig. 3 | Respiratory Research

Fig. 3

From: The LIM-domain only protein 4 contributes to lung epithelial cell proliferation but is not essential for tumor progression

Fig. 3

Loss of Lmo4 results in delayed repair after naphthalene-induced injury. a Representative immunofluorescence staining showing co-expression of Lmo4 (red) and Ki67 (green) in cells lining the airways of mice treated with naphthalene at the indicated time points. Scale bars = 50μm. White arrows indicate Ki67/Lmo4 double positive cells. b Immunohistochemistry showing the expression of the club cell marker CC10 in control and Shh-cre;Lmo4 fl/fl lung sections 4, 5 and 6 days following naphthalene administration. Scale bars = 50μm. c BrdU staining of control and Shh-cre;Lmo4 fl/fl lung sections five days following naphthalene administration. Scale bars = 50μm. Arrows indicate BrdU-positive cells. d Bar graph showing the number of BrdU-positive cells per airway circumference of control and Shh-cre;Lmo4 fl/fl mice five days following naphthalene injury. Data represent mean ± S.E.M., n ≥ 39 airways per group from at least three animals per group. e Bar graph showing the number of BrdU-positive cells per airway circumference of control and Scgb1a1-cre ER ;Lmo4 fl/fl mice five days following naphthalene injury. Data represent mean ± S.E.M., n ≥ 47 airways per group from at least three animals per group. p-value computed by Wilcoxon rank sum test

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