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Table 4 Correlations analyzed between the expression levels of the studied genes and tumor clinicopathological parameters and patients’ characteristics

From: Quantitative analysis of mRNA expression levels and DNA methylation profiles of three neighboring genes: FUS1, NPRL2/G21 and RASSF1A in non-small cell lung cancer patients

FUS1 (n = 59)

NPRL2/G21 (n = 59)

RASSF1A (n = 59)

Median RQ in NSCLC samples

1.35

1.36

0.77

SCC vs AC vs LCC

1.18 vs 1.83 vs 2.39 P = 0.002a

1.28 vs 1.79 vs 0.83 P = 0.05a

0.68 vs 1.01 vs 0.86 P = 0.01a

SCC vs AC

1.18 vs 1.83 P = 0.004b

1.28 vs 1.84 P = 0.03b

0.68 vs 1.01 P = 0.002b

SCC vs NSCC

1.18 vs 2.13 P = 0.001b

P > 0.05

0.68 vs 1.01 P = 0.002b

Age (≤60 yrs vs 61–70 yrs vs >70 yrs) – in total NSCLC group; in NSCLC histopathological subgroups

P > 0.05

In SCC: 61–70 yrs vs >70 yrs

P > 0.05

1.55 vs 0.99 P = 0.001b

Gender (females vs males) – in total NSCLC group; in NSCLC histopathological subgroups

P > 0.05

P > 0.05

In SCC: 1.04 vs 0.64 P = 0.02b;

in AC: 0.86 vs 1.31 P = 0.01b;

in NSCC: 0.86 vs 1.31 P = 0.02b

pTNM classification (T1 vs T2 vs T3/4) – in total NSCLC group; in NSCLC histopathological subgroups

P > 0.05

P > 0.05

0.80 vs 0.67 vs 0.94 P = 0.04a;

T2 vs T3/4 P = 0.01b;

in NSCC: 1.35 vs 0.75 vs 1.27 P = 0.04a; T2 vs T3/4 P = 0.04b

AJCC classification (I vs II vs III) – in total NSCLC group; in NSCLC histopathological subgroups

In NSCC: 2.44 vs 1.20 vs 2.25 P = 0.04a; I vs II P = 0.02b

P > 0.05

P > 0.05

Smoking status (current smokers vs former smokers vs never smokers) – in total NSCLC group; in NSCLC histopathological subgroups

P > 0.05

P > 0.05

P > 0.05

Smoking history (PYs: <40 vs ≥40) – in total NSCLC group; in NSCLC histopathological subgroups

P > 0.05

P > 0.05

P > 0.05

Tumor (T) tissue vs macroscopically unchanged lung tissue – in total NSCLC group; in NSCLC histopathological subgroups

in AC: 1.83 vs 1.18 P = 0.01b;

1.36 vs 0.84 P = 0.0003b;

0.77 vs 1.07 P = 0.0003b;

in NSCC: 2.13 vs 1.20 P = 0.002b

in SCC: 1.28 vs 0.84 P = 0.01b;

in SCC: 0.68 vs 1.09 P = 0.000002b

in AC: 1.84 vs 0.84 P = 0.002b;

in NSCC: 1.79 vs 0.84 P = 0.009b

  1. aKruskal-Wallis test; bMann–Whitney U-test