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Fig. 4 | Respiratory Research

Fig. 4

From: Autophagy contributes to the chemo-resistance of non-small cell lung cancer in hypoxic conditions

Fig. 4

Knockdown of LC3B restored cancer cells sensitivity to cisplatine under hypoxia. a: A549 cells were transfected with siRNA negative control or siRNA for LC3B and treated with indicated concentrations of cisplatin under normoxia or hypoxia for 8 h. Cell death was measured by MTT assays. Percent cell death is shown as mean ± SEM of at least 3 independent determinations. b: Western blots of LC3B-I to LC3B-II conversion in A549 cells transfected with LC3B siRNA in hypoxia compared with siRNA negative control under normoxia or hypoxia, *p < 0.05

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