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Table 1 Categorization of asthma severity based upon background therapy and lung function

From: Asthma characteristics and biomarkers from the Airways Disease Endotyping for Personalized Therapeutics (ADEPT) longitudinal profiling study

 

Pre-BD FEV1 ≥ 80 % predicted normal

Pre-BD FEV1 ≥ 60- < 80 % predicted normal

Pre-BD FEV1 ≥ 50- < 60 % predicted normal

Pre-BD FEV1 < 50 % predicted normal

Controller medication

None

Eligible for mild asthma cohort

Ineligible

Ineligible

Ineligible

Low to medium ICS alone or in combination with other controllers except chronic oral corticosteroids and omalizumab

Ineligible

Eligible for moderate asthma cohort

Ineligible

Ineligible

High dose ICS alone or in combination with other controllers including chronic oral corticosteroids and omalizumab

Ineligible

Eligible for severe asthma cohort

Eligible for severe asthma cohort

Ineligible