Cohorts | Healthy | Mild | Moderate | Severe | P-value*** |
---|---|---|---|---|---|
N | 30 | 52 | 55 | 51 | Â |
Pre-BD FEV1 (L) | 3.98 (0.81) * | 3.35 (0.81) | 2.39 (0.62) | 2.10 (0.71) | <0.0001 |
Pre-BD FEV1 (% predicted normal) | 103.3 (13.4) | 92.7 (14.3) | 73.6 (10.4) | 65.4 (12.7) | <0.0001 |
Post-BD FEV1 (L) | 4.10 (0.84) | 3.61 (0.87) | 2.67 (0.66) | 2.43 (0.81) | <0.0001 |
Post-BD FEV1 (% predicted normal) | 106.2 (13.7) | 101.4 (14.0) | 82.7 (10.2) | 75.7 (15.4) | <0.0001 |
Pre-BD FEV/FVC ratio | 0.83 (0.06) | 0.77 (0.08) | 0.66 (0.09) | 0.61 (0.09) | <0.0001 |
Post-BD FVC (% predicted normal) | 103.8 (15.9) | 105.0 (15.5) | 96.4 (11.4) | 94.0 (15.1) | 0.0004 |
BDR (%) | 2.9 (4.1) | 8.5 (8.3) | 15.2 (10.3) | 18.3 (14.5) | 0.0016 |
BDR (mL) | 114.8 (140.6) | 265.1 (231.7) | 335.2 (234.3) | 355.7 (270.6) | 0.45 |
PC20 methacholine (mg/mL) | NA | 1.68 (+10.85/-0.26)** | 0.93 (+6.49/-0.13)** | 0.63 (+2.62/-0.15)** | 0.034 |
ACQ7 | NA | 0.84 (0.69) | 1.33 (0.71) | 1.92 (1.01) | <0.0001 |
Controlled ACQ <0.75 (N, %) | NA | 29 (56Â %) | 10 (18Â %) | 4 (8Â %) | Â |
Partially controlled ACQ 0.75-1.5 (N, %) | NA | 13 (25Â %) | 24 (44Â %) | 16 (31Â %) | <0.0001 |
Uncontrolled ACQ ≥ 1.5 (N, %) | NA | 10 (19 %) | 21 (38 %) | 31 (61 %) |  |
AQLQ | NA | 5.86 (0.93) | 5.68 (1.11) | 5.09 (1.28) | 0.0016 |